The One Street Museum is another main attraction of the Andriyivskyy Descent, which houses many of the historic items of the descent, containing more than 6,500 exhibits. They include information about the Saint Andrew's Church, the castle of Richard Lionheart, and the many other buildings of the Descent.
Also, the museum has a unique collection of various works by Ukrainian philologist P. Zhitetsky, Arabist and professor of the Kiev University T. Kezma, journalist and public figure A.Savenko, Ukrainian writer G.Tyutyunnyk, which have lived in the house №34 in the different periods of the twentieth century. Another important part of the collection in the museum are the is the memorabilia of professors of Kiev Theological Academy A. Bulgakov, S. Golubev, P. Kudryavtsev, F. Titov, A.Glagolev, famed doctors Th. Janovsky and D. Popov, and other prominent local figures.
The museum also has a large collection of antique books. Book relics of the exposition include a famous Trebnik of the Metropolitan of Kiev Petro Mohyla, rare editions of works written by professors and graduates of the Kiev-Mohyla Academy, unique books written by the Ukrainian Walter Scott, M.Grabovsky, the Defender of Orthodoxy, A.Muravyov, and the works of Mikhail Bulgakov published in his lifetime.